PolyPhil® is an injectable gel made of long-chain polynucleotides (PN) — nucleic acid molecules derived from purified, natural sources. It's produced using Croma's PN-HPT® (Polynucleotide High Purification Technology), a manufacturing process designed to achieve a high level of purification.

Importantly, PolyPhil® is not a dermal filler. Where fillers like Juvederm add volume and fullness, PolyPhil® works by stimulating fibroblasts — the skin cells responsible for producing collagen — to improve skin tone, texture, hydration, and elasticity over time, rather than reshaping facial contours.

How It Works

Polynucleotides support the skin in a few key ways:

• Stimulating fibroblast activity, which drives collagen and elastin production
• Deeply hydrating the skin and helping neutralize free radicals
• Creating a more favorable environment for skin cell regeneration and repair

This makes PolyPhil® particularly suited to areas with thin, delicate, or aging skin — including under the eyes, neck, and areas affected by fine lines or acne scarring.

What to Expect

Initial effects are often visible after the first session, but for optimal results, a course of 3-4 treatments spaced 2-3 weeks apart is typically recommended. Results build progressively as collagen and skin regeneration continue over the following weeks.

PolyPhil® vs. Other Skin Boosters

It's a fair question if you've researched skin boosters before: how does this differ from something like Profhilo or Rejuran? In broad terms, hyaluronic acid-based boosters like Profhilo primarily hydrate and lightly firm the skin, while polynucleotide-based treatments like PolyPhil® are proposed to work more on stimulating the skin's own regenerative and collagen-producing processes. Different polynucleotide products also vary by source and purification method — worth discussing directly with your doctor to determine which suits your specific skin concerns.